Update:
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A lot of improvements in the node are done (starting from 4.0.8), some going on. We are going to count every memory allocation and every operation. I guess 20-50x improvements are still possible by just optimizing the node code.
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Implementations for bootstrapping with NiPoPoW proofs and UTXO set snapshots are planned.
Then we can think about sub-block confirmation protocols and L2.